Genomic Testing

Genomic testing, is it worthwhile?

To say the past decade has been revolutionary in the world of cattle genetics is no understatement. Genomic testing, along with subsequent data collection, has been the spearhead of this rapid acceleration, moving the modern cow’s improvement by leaps and bounds.

The dairy industry has especially fallen in love with this technology. And while beef is certainly heading that direction, it has not yet reached the same widespread genomic heights of its dairy counterpart.

There is much to evaluate in terms of where genomics stand in today’s beef and where things are going. For many breeders, an investment in genomics is an investment in the future.

What that future might be depends on how producers and professionals use and interpret that information. With so much potential going on, it’s worth individual producers to ask – is genomic testing worthwhile?

Decoding information and making it all work

Researchers have used genomics and all its accompanying technology for while. Right now, the beef industry is a good position to take the next steps and decide how and where to use that information on the industrial and production levels.

Typical genomic testing for cattle uses Single Nucleotide Polymorphism (SNP) technology  https://en.wikipedia.org/wiki/Single-nucleotide_polymorphism .  SNP technology uses DNA markers to translate the unique genetic makeup of the individual animal. It can also be used to identify genetic abnormalities and mutations.

Research has told us a lot about how to translate genomic results.  Producers can have an idea of how certain animals will perform in specific management situations.

For example, according the Beef Cattle Research Council (BCRC),  https://www.beefresearch.ca/  leptin gene codes for a hormone that controls appetite and fat deposits.

In cattle, the base pair code of CC, TC or TT, and TT calves can deposit backfat faster and be on feed fewer days than TC and CC calves.

This kind of testing can help feedlot operators and cow-calf producers sort calves into more uniform feeding groups for optimal performance.

In a similar way, a lot of dairies have invested in genomic testing to assist with making their culling and replacement decisions.

There have been massive changes in even traits of low heritability. Fertility, productive life and health are among these.  Researchers are pouring lot of time and research into feed efficiency.

 Genomic enhancement can improve the reliability of traditional EPDs. 

Individual producers can contribute lot of merit to the national herd and industry standards. Data collection provides the information we have from genomics and their reliability.

Collecting more data allows us to learn more and increases our reliability.

Genomics are very reliable

Genomics offers benefits but genomic number on test or pedigree shouldn’t dominate decision-making.

As we develop and learn more about this technology we continue to discuss the best way to apply it. 

The BCRC states that genomics works very reliably in cases where the SNP is known to occur within an actual gene. 

The BCRC mentions that in many cases the SNP may only be located somewhere near the gene. The accuracy of GE-EPDs or MBVs depends on the closeness of the tested animals’ relation to the population in which the prediction equations were developed. SNPs discovered in one bloodline may not allow GE-EPD/MBV prediction equations to work reliably in another. SNPs discovered in one breed are unlikely to help GE-EPD/MPV prediction equations produce reliable results in different breed.

”There are different genomics tests available at different costs, the larger the chip used for the test, the more markers can be identified to obtain more information.

Tests can range from less than $20 to nearly $40and as simple as submitting a hair or blood sample. Many breed associations work with labs and make the sampling and testing process easy,

sometimes at a discount when obtained through other services.

Beyond the bottom line

Genomics solves certain genetic issues found in livestock and provides productivity advantages. 

One USDA statistic suggests that one in every five animals will carry genetic defect capable of causing embryonic loss. 

Genomics allows us to identify animals going into stud service very quickly. 

These predictions are so accurate that farmers need not even cull animals carrying undesirable traits. They can manage their mating to pass down positive traits and mitigate negative ones.

 Genomics can help reduce the amount of inbreeding.

Health traits and diseases resistance are another area genomics are rapidly working to accelerate. A lot of health and wellness traits tend to have very low heritability.

It can take many years of pristine breeding for them to gain little impact in the traditional way. For a long time, they weren’t even major players in sire se-lection.

In less than a decade, they’ve seen massive improvements.

Other welfare-related traits are also on the genomics docket. This includes things like heat tolerance and hoof durability.

Some researchers currently study complex genetically-influenced behaviors such as grazing ability and efficiency.

Genomic knowledge has already made an incredible impact. The era is still in its infancy. Researchers will learn and discover much more. 

Beef will only invest more into genomics through both research and field testing.

There’s enough of a future in the technology making it worth a serious look and consideration. Even if not applicable to one’s specific operation and market, directly or indirectly.

You can expect genomics to have an impact in the future.

 

American Cattlemen, January 2020

https://americancattlemen.com/

Neogen® Introduces Igenity® BCHF to Help Industry Mitigate Bovine Congestive Heart Failure Risk

Lincoln, Neb., Jan. 14, 2025 — With unmatched commitment to serving the cattle industry with impactful herd health and genomic solutions, Neogen (NASDAQ: NEOG) announces its launch of Igenity BCHF to uplift overall bovine heart health standards. Bovine Congestive Heart Failure (BCHF) stands as a significant threat to cattle health and productivity, and this new genomic test unveils opportunity for improved selection for heart health.
“Igenity BCHF is a revolutionary genomic test designed to assess an animal’s genetic predisposition to heart failure,” says Victor Pedrosa, PhD, Director of Technical Genomics and Innovation with Neogen. “The test results directly correlate with the percentage of BCHF risk an animal carries and should pass on to their progeny, serving as a genetic indicator of the likelihood of disease development.”
Testing with Igenity BCHF assesses animals’ genetic predisposition for BCHF. Test results are scored on a 1-to-10 scale, ranging from 1 (lowest risk) to 10 (highest risk of symptom development), where each decrease in score translates to an expected 3.5% lower BCHF incidence. Case study results demonstrated the variability for risk in a feedlot setting, where animals with an Igenity score of 2 characterized a genetic effect of 3.5% for BCHF predisposition and animals with an Igenity score of 7 signified a genetic effect of 21.2% for BCHF predisposition.  This demonstrated a 17.7% lower probability of exhibiting BCHF with an Igenity score decrease of 5.
Operational Advantages Using Igenity BCHF 
In severely affected cattle pens, mortality rates have surged up to 7%, translating to staggering annual losses surpassing $250,000 for a single operation. In addition to death losses due to BCHF, there are also significant economic risks and performance losses possible, such as a reduction in average daily gain by 0.2 lbs per day and lighter hot carcass weights by up to 38 lbs. Igenity BCHF provides producers with the opportunity to effectively manage the risk of BCHF within their herd, confidently produce feeder calves that will have a lower risk of mortality from BCHF in a feedlot setting, and decrease economic losses attributed to BCHF. 
Core advantages include: 
  • Easy to interpret 1-10 scores
  • Cull high scoring and keep low scoring replacement heifers with a genetic predisposition to produce calves with a lower risk of BCHF
  • Group cattle based on their Igenity BCHF scores to better manage potential health issues in high-risk cattle
  • Manage mortality and morbidity rates related to BCHF in offspring through targeted management strategies (i.e., enhanced monitoring, tailored nutrition plans, and reduced stress)
  • Mitigate economic losses related to cattle death or decreased performance due to BCHF related complications
  • Increase overall bovine heart health standards by selecting animals with lower prevalence of heart failure-related genes
Industry-wide Impact 
BCHF presents a growing threat to the health and productivity of all segments of the cattle industry, from young calves on pasture to late-fed cattle. “When we look at the impact of Igenity BCHF on the industry, it is helping to genetically quantify the risk for bovine congestive heart failure and progress herds away from this growing cattle health and welfare concern,” says Kirk Ramsey, DVM, Professional Services Veterinarian with Neogen. “Igenity BCHF is the first genomic test of its kind and is the first step in capturing the reason why congestive heart failure is occurring in these young calves and late-fed cattle.”
By employing DNA testing for BCHF in cattle, producers gain the confidence to pinpoint animals harboring genetics conducive to enhancing bovine heart health.
Database Powering Igenity BCHF 
The prediction equation powering the Igenity BCHF genomic test is a two-trait genomic evaluation informed by heart score, lung score, and breed percentage. Backing Igenity BCHF is a robust database of 32,763 phenotypes and 25,186 genotypes assembled from animals fed at a single commercial feedlot and harvested at a single facility, which represents one of the largest single-source commercial data sets of its kind. A subset of this reference population was also selected for genomic sequencing to determine the heritability and genetic correlations of the phenotypes collected and complete a genome-wide association study (GWAS). Moderate heritability estimates of both heart score (0.36) and lung score (0.27) were observed and further reinforced the application of these phenotypes in the Igenity BCHF prediction. In addition to capturing variation in heart morphology, a novel scoring system was developed describing pulmonary changes exhibited; with this, a lung deflation score was assigned. 
“Igenity BCHF represents additive polygenic effects across the entire genome rather than the single-nucleotide polymorphism (SNP) markers previously discovered. With the more robust marker sets, polygenic effects are better characterized,” says Kelsey Luebbe, PhD, Genomics Technical Services Scientist with Neogen.
To learn more about Igenity BCHF, visit neogen.com/igenity-beef or contact your Neogen representative. 
About Neogen
Neogen Corporation is committed to fueling a brighter future for global food security through the advancement of human and animal well-being. Harnessing the power of science and technology, Neogen has developed comprehensive solutions spanning the Food Safety, Livestock, and Pet Health & Wellness markets. A world leader in these fields, Neogen has a presence in over 140 countries with a dedicated network of scientists and technical experts focused on delivering optimized products and technology for its customers.
Media Contact:
Aimee Robinson, Senior Marketing Manager – Livestock
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